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The NCI Transcriptional Pharmacodynamics Workbench website has been developed using advanced computational and visualization tools for empowering developmental therapeutics investigators worldwide and providing them access to the genome-wide characterization of the NCI-60 cell lines and the enormous time-course databases on genome-wide response to treatment with drugs.
Principal Architect: Dr. Richard Simon
Development team: Drs. Yingdong Zhao, Eric Polley, Ming-Chung Li, Jianwen Fang, Xiaosheng Wang, Alida Palmisano, Peter Szabo; Mr. Henry Rivera
For questions or assistance, please contact the Support Team at ncitpwsupport@mail.nih.gov
Documentation: NCI Transcriptional Pharmacodynamics Workbench User Manual
When publishing results based on the NCI TP Workbench, please cite:
Monks, A, et al. "The NCI Transcriptional Pharmacodynamics Workbench: a tool to examine dynamic expression profiling of therapeutic response in the NCI-60 cell line panel." Cancer Research (2018): canres-0989.
https://www.ncbi.nlm.nih.gov/pubmed/30355619
** October 2021 **
TPWshiny: an interactive RShiny app to explore the therapeutic response of NCI-60 cell lines
TPWshiny is a powerful standalone visualization tool for the genome-wide characterization of NCI-60 human cell lines and response to 15 different anticancer drugs at different time points. TPWshiny is an easy to install, R Shiny application to facilitate more interactive exploration of data from the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW).
Access or download TPWshiny at https://brb.nci.nih.gov/TPWshiny/.